Bioactive glass for dentin remineralization: A systematic review

With a growing interest in using bioactive glass for dentin remineralization, this systematic review was performed to assess from the results in this field if there is evidence for bioactive glass stimulating dentin remineralization. We set high standards for inclusion criteria in order to avoid bias on the results. By following this rigorous methodology we arrived at 3 key papers that fulfilled our criteria to be included in this review. All the three papers included in this review have confirmed that bioactive glass results in enhanced apatite formation in dentin (Fig. 1) which is one important aspect for remineralization. From the 3 key papers in this review the data on the mechanical characterization of dentin after BAG treatment for remineralization was available from only one paper (Figure 1). The lack of such important evaluations limits us from drawing firm conclusions.

F1 Delihta Fernando


The present systematic review highlights that bioactive glass treatment can increase apatite content in dentin; however, the potential of these particles to remineralize dentin in an intrafibrillar manner is unclear mainly due to lack of in-depth investigations to probe this aspect. From this review it is clear that for dentin remineralization using bioactive glass research studies need to augment the established apatite structure by probing the mechanical aspects of the mineralized dentin so that the potential of bioactive glass for dentin remineralization can be truly realized.


The research leading to this review has received funding from the European Union Seventh Framework Program (FP7/2007-2013) under grant agreement no. 608197.


Fernando, D.; Attik, N.; Pradelle-Plasse, N.; Jackson, P.; Grosgogeat, B.; Colon, P. Bioactive glass for dentin remineralization: A systematic review. Mater. Sci. Eng. C 2017, 76, 1369–1377 DOI: 10.1016/j.msec.2017.03.083.